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anti amebics effective in both tissues and the intestinal lumen include metronidazole and the nitroimidazole derivatives tinidazole and ornidazole.

In addition to being active both in tissues and the intestinal lumen, these drugs have the advantage that they are give orally and are most effective therapeutically.

amebic drugs vary in efficacy at the three sites where parasites commonly exist and generally are divide into two classes based on their main site of activity.

Luminal amebic act principally in the bowel lumen, and tissue  amebic act principally in the bowel wall and in the liver.

According to the site where the drug is effective, the amebic drugs are classified as: Luminal amebicides (Act on parasite in the lumen of bowel).
kills trophozoites but not cysts of E histolytica and effectively eradicates intestinal and extraintestinal tissue infections.
Gastrointestinal amebic is treated with nitroimidazole drugs, which kill amebics in the blood, in the wall of the intestine and in liver abscesses.
These drugs include metronidazole (Flagyl) and tinidazole (Tindamax, Fasigyn).
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